Diabetes is a chronic metabolic disease characterized by high glucose concentration in blood. Conventional management of diabetes requires skin pricking and subcutaneous injection, causing physical pain and physiological issues to diabetic individuals. Hydrogels possess unique advantages such as lightweight, stretchability, biocompatibility, and biodegradability, offering the opportunities to be integrated as flexible devices for diabetes management. This review highlights the development of hydrogels as flexible materials for diabetes applications in glucose monitoring, insulin delivery, wound care, and cell transplantation in recent years. Challenges and prospects in the development of hydrogel-based flexible devices for personalized management of diabetes are discussed as well.

糖尿病是一种慢性代谢性疾病，其特征是血液中葡萄糖浓度过高。传统的糖尿病管理需要刺破皮肤和皮下注射，这会给糖尿病患者带来身体疼痛和生理问题。水凝胶具有独特的优势，例如重量轻、可拉伸、生物相容性和生物降解性，为集成为糖尿病管理的灵活设备提供了机会。这篇综述强调了近年来水凝胶作为糖尿病应用在葡萄糖监测、胰岛素输送、伤口护理和细胞移植中的柔性材料的发展。还讨论了开发用于糖尿病个性化管理的基于水凝胶的柔性设备的挑战和前景。