Two recent studies addressed the functional properties and clinical significance of tumour antigen-specific effector T cells in human melanomas and lung carcinomas using single-cell strategies. Herein, we discuss their findings, which expand our understanding of T cell alterations in the tumour microenvironment and demonstrate that CD8+ T cell exhaustion is mediated by exposure to tumour cell-specific antigens and is associated with a tissue-resident memory phenotype.

中文翻译：

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肿瘤抗原诱导的 T 细胞衰竭——免疫热恶性肿瘤的大敌

最近的两项研究使用单细胞策略解决了人类黑色素瘤和肺癌中肿瘤抗原特异性效应 T 细胞的功能特性和临床意义。在这里，我们讨论了他们的发现，这扩大了我们对肿瘤微环境中 T 细胞改变的理解，并证明 CD8+ T 细胞耗竭是由暴露于肿瘤细胞特异性抗原介导的，并且与组织驻留记忆表型相关。