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Erratum
The FASEB Journal ( IF 4.4 ) Pub Date : 2021-09-23 , DOI: 10.1096/fsb2.21963


Correction for “Mechanisms underlying auditory processing deficits in Fragile X syndrome” by Elizabeth A. McCullagh, Sarah E. Rotschafer, Benjamin D. Auerbach, Achim Klug, Leonard K. Kaczmarek, Karina S. Cramer, Randy J. Kulesza Jr., Khaleel A. Razak, Jonathan W. Lovelace, Yong Lu, Ursula Koch, and Yuan Wang, which was first published February 20, 2020; 10.1096/fj.2021902435R (FASEB J.34:3501–3518).

The authors report an incorrect statement in the submitted manuscript, in the last paragraph of Section 3.3, “FMRP loss affects ABR measurements in FXS and Fmr1 knockout mice” (page 10 of the published article). The manuscript states, “Similar to human studies, peak latencies appear to be a subject of FMRP loss in FVB mice,108 but not in B6 mice.55,64” However, to date, there have been no studies of ABRs using B6 FXS mice, and all three studies (references 108, 55, and 64) were performed on FVB mice. Therefore, the sentence should correctly read, “Peak latencies appear to be a subject of FMRP loss in FVB mice in one study,108 but not in other studies.55,64

The corrected paragraph is as follows:

Studies with mice are not confounded by some of the variables that affect human studies. Several ABR alterations have been identified by comparing Fmr1 knockout mice and age-matched wild types under anesthesia. Similar to human studies, peak latencies appear to be a subject of FMRP loss in one study,108 but not in other studies.55,64 Interestingly, although there is no report of altered ABR wave amplitudes in human FXS, the amplitudes of several ABR peaks are altered in Fmr1 knockout mice, including decreased peak I and increased peak IV, suggesting impaired peripheral and central auditory systems. As the methodology for collecting ABRs can be quite variable, future work using similar experimental protocols on mice and humans may be useful for further characterization of the auditory brainstem phenotype in FXS.



中文翻译:

勘误表

Elizabeth A. McCullagh、Sarah E. Rotschafer、Benjamin D. Auerbach、Achim Klug、Leonard K. Kaczmarek、Karina S. Cramer、Randy J. Kulesza Jr.、Khaleel 对“脆性 X 综合征听觉处理缺陷的潜在机制”的修正A. Razak、Jonathan W. Lovelace、Yong Lu、Ursula Koch 和 Yuan Wang,于 2020 年 2 月 20 日首次出版;10.1096 / fj.2021902435R(FASEBĴ34:3501-3518)。

作者在提交的手稿中报告了错误的陈述,在第 3.3 节的最后一段,“FMRP 损失影响 FXS 和Fmr1基因敲除小鼠的ABR 测量”(已发表文章的第 10 页)。该手稿指出,“与人类研究类似,峰值延迟似乎是 FVB 小鼠108 FMRP 损失的一个主题,但在 B6 小鼠中则不然。55,64 ”然而,迄今为止,还没有使用 B6 FXS 小鼠的 ABR 研究,所有三项研究(参考文献108、55和 64)都是在 FVB 小鼠上进行的。因此,这句话应该正确阅读,“在一项研究中,峰值潜伏期似乎是 FVB 小鼠 FMRP 损失的一个主题,108但在其他研究中则不然。55,64

更正后的段落如下:

对小鼠的研究不会被影响人类研究的一些变量所混淆。通过比较麻醉下的Fmr1敲除小鼠和年龄匹配的野生型,已经确定了几种 ABR 改变。与人体研究类似,在一项研究中,峰值延迟似乎是 FMRP 损失的一个主题,108但在其他研究中则不然。55,64有趣的是,虽然没有在人类FXS改变ABR波振幅的报告,几个ABR峰幅度在改变Fmr1基因敲除小鼠,包括减少的峰值 I 和增加的峰值 IV,表明外周和中枢听觉系统受损。由于收集 ABR 的方法可能非常多变,未来在小鼠和人类上使用类似实验方案的工作可能有助于进一步表征 FXS 中的听觉脑干表型。

更新日期:2021-09-24
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