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Synergistic or Antagonist Effects of Different UV Ranges Analyzed by the Combination Index: Application to DNA Photoproducts†
Photochemistry and Photobiology ( IF 2.6 ) Pub Date : 2021-09-23 , DOI: 10.1111/php.13528
Thierry Douki 1 , Arnaud Buhot 1
Affiliation  

Photobiological effects are known to greatly depend on the wavelength of the incident photons that define the nature of the activated chromophores. A growing number of experimental data show that considering the effect of complex light sources as a sum of the effects of monochromatic exposures can be misleading. Indeed, the combined exposure to several wavelength ranges may modulate photobiological responses or even induce novel processes. These observations are similar to a well-known topic in chemical toxicology: the nonadditivity of effects in mixtures where either antagonism or synergy are often observed. In the present work, we investigated whether a data analysis tool first developed for studying nonadditivity in mixtures of drugs, the combination index, could be applied to photobiological processes. We chose to work on the formation of UV-induced DNA photoproducts where additive, antagonist, and synergistic effects take place simultaneously. In addition to this application, we worked on the mathematical bases of the concept in order to broaden its applicability to phenomena exhibiting various dose–response patterns. We also addressed the question of the evaluation of the error on the determination of the combination index.

中文翻译:

通过组合指数分析不同 UV 范围的协同或拮抗作用:应用于 DNA 光产品†

众所周知,光生物学效应在很大程度上取决于入射光子的波长,入射光子的波长决定了活化生色团的性质。越来越多的实验数据表明,将复杂光源的效果视为单色曝光效果的总和可能会产生误导。事实上,在几个波长范围内的组合暴露可以调节光生物学反应,甚至诱导新的过程。这些观察结果类似于化学毒理学中的一个众所周知的主题:在经常观察到拮抗或协同作用的混合物中,效果的非可加性。在目前的工作中,我们研究了一种最初开发用于研究药物混合物中的非相加性的数据分析工具,即组合指数,是否可以应用于光生物学过程。我们选择研究紫外线诱导的 DNA 光产物的形成,其中添加剂、拮抗剂和协同作用同时发生。除此应用外,我们还研究了该概念的数学基础,以扩大其对表现出各种剂量反应模式的现象的适用性。我们还解决了评估组合指数确定误差的问题。
更新日期:2021-09-23
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