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The Use of Standardized Diesel Exhaust Particles in Alzheimer’s Disease Research
Journal of Alzheimer’s Disease ( IF 4 ) Pub Date : 2021-09-22 , DOI: 10.3233/jad-215201
Michelle L Block 1, 2 , Urmila P Kodavanti 3
Affiliation  

The mechanisms underlying how urban air pollution exposure conveys Alzheimer’s disease risk and affects plaque pathology is largely unknown. Because particulate matter, the particle component of urban air pollution, varies across location, pollution source, and time, a single model representative of all ambient particulate matter is unfeasible for research investigating the role of ar pollution in central nervous system diseases. More specifically, the investigation of several models of particulate matter with enrichment of source-specific components are essential to employ, in order to more fully understand what characteristics of particulate matter affects Alzheimer’s disease, including standardized diesel exhaust particles.

中文翻译:

标准化柴油机尾气颗粒在阿尔茨海默病研究中的应用

城市空气污染暴露如何传递阿尔茨海默病风险和影响斑块病理学的机制在很大程度上是未知的。由于颗粒物(城市空气污染的颗粒成分)因地点、污染源和时间而异,因此一个代表所有环境颗粒物的单一模型对于调查 ar 污染在中枢神经系统疾病中的作用的研究是不可行的。更具体地说,为了更全面地了解颗粒物的哪些特征会影响阿尔茨海默病,包括标准化的柴油机尾气颗粒,必须研究几种富含源特定成分的颗粒物模型。
更新日期:2021-09-24
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