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The Alzheimer– E. coli Axis: What Can We Learn from an Electronic Health Record Platform
Journal of Alzheimer’s Disease ( IF 4 ) Pub Date : 2021-09-22 , DOI: 10.3233/jad-215004
Joseph Katz 1 , Hanzhi Gao 2
Affiliation  

Background:Alzheimer’s disease (AD) is a neurodegenerative disease with unclear etiology. Recent studies have demonstrated a potential role for gut microbiome. There is, however, a significant dearth in epidemiological correlation between gut bacteria and AD. Objective:To investigate the association between Escherichia coli (E. coli) infection and AD. Methods:Counts of patients with ICD 10 diagnoses of AD, E. coli, urinary tract infection, and comorbidities were retrieved from the electronic health records at the University of Florida Health Center. Results:The relative risk for AD with a previous event of E. coli was 5.17 (95%CI 4.0786 to 6.5446, p < 0.0001). In the unadjusted association, patients with E. coli infection had odds ratio (OR) of 20.83 to have AD (95%CI, 17.7–24.34; p < 0.0001); after adjusting for gender (OR = 12.71; 95%CI, 10.82–14.83; p < 0.0001), race (OR = 13.97; 95%CI, 11.84–16.36; p < 0.0001), age group (OR = 11.51; 95%CI, 9.73–13.54; p < 0.0001), diabetes (OR = 9.23; 95%CI, 7.79–10.87; p < 0.0001), stroke (OR = 5.31; 95%CI, 4.47–6.28; p < 0.0001), and hypertension (OR = 4.55; 95%CI, 3.86–5.32; p < 0.0001). Conclusion:These results should be taken cautiously. This retrospective cross-sectional study cannot infer causality and had used aggregate data that did not allow simultaneous adjustments of covariates. Future studies are warranted to investigate the link between gut bacteria and AD.

中文翻译:

阿尔茨海默病-大肠杆菌轴:我们可以从电子健康记录平台中学到什么

背景:阿尔茨海默病(AD)是一种病因不明的神经退行性疾病。最近的研究证明了肠道微生物组的潜在作用。然而,肠道细菌与 AD 之间的流行病学相关性显着缺乏。目的:探讨大肠杆菌(E.coli)感染与AD的相关性。方法:从佛罗里达大学健康中心的电子健康记录中检索 ICD 10 诊断为 AD、大肠杆菌、尿路感染和合并症的患者的计数。结果:AD 与既往大肠杆菌事件的相对风险为 5.17(95%CI 4.0786 至 6.5446,p < 0.0001)。在未经调整的关联中,大肠杆菌感染患者患 AD 的优势比 (OR) 为 20.83(95%CI,17.7-24.34;p < 0.0001);调整性别后(OR = 12.71;95%CI,10.82–14.83;p < 0.0001)、种族 (OR = 13.97; 95%CI, 11.84–16.36; p < 0.0001), 年龄组 (OR = 11.51; 95%CI, 9.73–13.54; p < 0.0001), 糖尿病 (OR = 9.23; 95%CI,7.79–10.87;p < 0.0001),中风(OR = 5.31;95%CI,4.47–6.28;p < 0.0001)和高血压(OR = 4.55;95%CI,3.86–5.32;p < 0.0001 )。结论:应谨慎对待这些结果。这项回顾性横断面研究无法推断因果关系,并且使用了不允许同时调整协变量的汇总数据。未来的研究有必要调查肠道细菌与 AD 之间的联系。和高血压(OR = 4.55;95%CI,3.86–5.32;p < 0.0001)。结论:应谨慎对待这些结果。这项回顾性横断面研究无法推断因果关系,并且使用了不允许同时调整协变量的汇总数据。未来的研究有必要调查肠道细菌与 AD 之间的联系。和高血压(OR = 4.55;95%CI,3.86–5.32;p < 0.0001)。结论:应谨慎对待这些结果。这项回顾性横断面研究无法推断因果关系,并且使用了不允许同时调整协变量的汇总数据。未来的研究有必要调查肠道细菌与 AD 之间的联系。
更新日期:2021-09-24
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