Ir(III) and Ru(II) Complexes in Photoredox Catalysis and Photodynamic Therapy: A New Paradigm towards Anticancer Applications,ChemBioChem

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Ir(III) and Ru(II) Complexes in Photoredox Catalysis and Photodynamic Therapy: A New Paradigm towards Anticancer Applications
ChemBioChem ( IF 2.6 ) Pub Date : 2021-09-24 , DOI: 10.1002/cbic.202100469
Md Kausar Raza ₁ , Aisha Noor ₂ , Paresh Kumar Samantaray ₁

Affiliation

Light triggered Ir(III)- and Ru(II)-based organometallic complexes that elicit selective in vitro and in vivo responses to cancerous cells while being nontoxic to normal cells in photodynamic therapy (PDT) and photoredox catalysis (PC) are discussed in this Highlight article. We indicate promising avenues in translational research for cancer treatment by examining stable transition-metal complexes that hold potential for clinical trials in the future.

中文翻译：

光氧化还原催化和光动力治疗中的 Ir(III) 和 Ru(II) 配合物：抗癌应用的新范式

本文讨论了基于光触发Ir(III) 和 Ru(II) 的有机金属配合物，它们在光动力疗法 (PDT) 和光氧化还原催化 (PC) 中引发对癌细胞的选择性体外和体内反应，同时对正常细胞无毒。突出文章。我们通过检查具有未来临床试验潜力的稳定过渡金属配合物，为癌症治疗的转化研究指明了有希望的途径。

更新日期：2021-12-02

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