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Modeling-Assisted Design of Thermostable Benzaldehyde Lyases from Rhodococcus erythropolis for Continuous Production of α-Hydroxy Ketones
ChemBioChem ( IF 2.6 ) Pub Date : 2021-09-24 , DOI: 10.1002/cbic.202100468 Martin Peng 1 , Dominik L Siebert 1 , Martin K M Engqvist 2 , Christof M Niemeyer 1 , Kersten S Rabe 1
ChemBioChem ( IF 2.6 ) Pub Date : 2021-09-24 , DOI: 10.1002/cbic.202100468 Martin Peng 1 , Dominik L Siebert 1 , Martin K M Engqvist 2 , Christof M Niemeyer 1 , Kersten S Rabe 1
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A novel benzaldehyde lyase for the production of chiral α-hydroxy ketones was identified by a machine learning model and two variants with altered substrate scopes were created by rational design. All three variants exhibit significantly higher thermostability compared to the only previously described benzaldehyde lyase. When immobilized in a packed-bed reactor, the most thermostable variant showed stable substrate turnover over days.
中文翻译：
红平红球菌热稳定性苯甲醛裂解酶的建模辅助设计，用于连续生产 α-羟基酮
通过机器学习模型鉴定了一种用于生产手性 α-羟基酮的新型苯甲醛裂合酶，并通过合理设计创建了两种底物范围改变的变体。与之前描述的苯甲醛裂合酶相比，所有三种变体均表现出显着更高的热稳定性。当固定在填充床反应器中时，最热稳定的变体在数天内表现出稳定的底物周转率。
更新日期：2021-09-24
中文翻译：
红平红球菌热稳定性苯甲醛裂解酶的建模辅助设计，用于连续生产 α-羟基酮
通过机器学习模型鉴定了一种用于生产手性 α-羟基酮的新型苯甲醛裂合酶，并通过合理设计创建了两种底物范围改变的变体。与之前描述的苯甲醛裂合酶相比，所有三种变体均表现出显着更高的热稳定性。当固定在填充床反应器中时，最热稳定的变体在数天内表现出稳定的底物周转率。
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