Structural Basis of Cyclic 1,3-Diene Forming Acyl-Coenzyme A Dehydrogenases,ChemBioChem

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Structural Basis of Cyclic 1,3-Diene Forming Acyl-Coenzyme A Dehydrogenases
ChemBioChem ( IF 2.6 ) Pub Date : 2021-09-23 , DOI: 10.1002/cbic.202100421
Johannes W Kung ₁ , Anne-Katrin Meier ₁ , Max Willistein ₁ , Sina Weidenweber ₂ , Ulrike Demmer ₂ , Ulrich Ermler ₂ , Matthias Boll ₁

Affiliation

Expanding the biocatalytic repertoire: Canonical acyl-coenzyme dehydrogenases catalyze the 1,2-dehydrogenation of aliphatic thioesters in a highly conserved manner with a invariant glutamate serving as catalytic base and a flavin as hydride acceptor. By removal of this glutamate and positioning of a novel aspartate base at C3, an 1,4 dehydrogenation activity is achieved, thereby generating a cyclic 1,3-diene building block.

中文翻译：

环状 1,3-二烯形成酰基辅酶 A 脱氢酶的结构基础

扩展生物催化库：典型的酰基辅酶脱氢酶以高度保守的方式催化脂肪族硫酯的 1,2-脱氢，其中不变的谷氨酸盐作为催化碱，黄素作为氢化物受体。通过去除这种谷氨酸并将新的天冬氨酸碱基定位在 C3，实现了 1,4 脱氢活性，从而产生了环状 1,3-二烯结构单元。

更新日期：2021-11-16

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