Supernova: A Deoxyribozyme that Catalyzes a Chemiluminescent Reaction,Angewandte Chemie International Edition

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Supernova: A Deoxyribozyme that Catalyzes a Chemiluminescent Reaction
Angewandte Chemie International Edition ( IF 16.1 ) Pub Date : 2021-09-24 , DOI: 10.1002/anie.202109347
Katerina Svehlova _{1,

2} , Ondřej Lukšan ₁ , Martin Jakubec _{1,

2} , Edward A Curtis ₁

Affiliation

Artificial evolution was used to identify a light-producing deoxyribozyme called Supernova. This catalyzes a chemiluminescent reaction in the presence of the 1,2-dioxetane substrate CDP-Star. Light production can also be coupled to ligand binding, suggesting that Supernova will be a useful addition to the toolkit of functional DNA parts.