Antibacterial Zeolite Imidazole Frameworks with Manganese Doping for Immunomodulation to Accelerate Infected Wound Healing,Advanced Healthcare Materials

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Antibacterial Zeolite Imidazole Frameworks with Manganese Doping for Immunomodulation to Accelerate Infected Wound Healing
Advanced Healthcare Materials ( IF 10.0 ) Pub Date : 2021-09-23 , DOI: 10.1002/adhm.202101515
Yao Wan ₁ , Jiao Fang ₁ , Yu Wang ₂ , Jiao Sun ₃ , Yue Sun ₁ , Xiaolin Sun ₁ , Manlin Qi ₁ , Wen Li ₁ , Chunyan Li ₂ , Yanmin Zhou ₁ , Lin Xu ₄ , Biao Dong ₄ , Lin Wang ₁

Affiliation

Numerous nanomedicines currently emerge to reduce the dramatic threat in antibiotics resistance for antibacterial application against severe bacterial infections, while it is restricted by over-reacted immune response to pathogenic bacteria. Herein, enzymatic activity is introduced into the zeolitic imidazolate framework-8 (ZIF-8) to achieve sterilization by releasing Zn ions, as well as inflammation regulation through the variable valence of Mn ions that are uniformly doped into its framework. Within this simple metal organic framework (MOF) structure design, Mn-ZIF-8 possesses the co-existence of Mn²⁺/Mn⁴⁺ to endow the nanocomposite with the anti-inflammatory capabilities, which can be adjusted through the redox environment. The enzymatic activity of Mn ions and superiority of pore structure of ZIF-8 are effectively combined to realize the substrate selection via reactant molecular size and high-efficiency internal catalytic performance. By such design, this nanocomposite would not only exhibit an excellent antibacterial performance against pathogenic bacteria, but also reshape the inflammatory immunity by regulating macrophage polarization to suppress over-reacted inflammation, leading to a favorably therapeutic efficiency on bacteria-infected wound healing in animal models. Taken together, this nanoplatform provides effective approach for accelerating infected wound healing via bacteria killing and inflammation modulation, and may be extended for the therapy of other severe bacteria-induced infections.

中文翻译：

具有锰掺杂的抗菌沸石咪唑骨架用于免疫调节以加速感染伤口愈合

目前出现了许多纳米药物，以减少对严重细菌感染的抗菌应用的抗生素耐药性的巨大威胁，同时它受到对病原菌的过度反应的免疫反应的限制。在此，酶活性被引入沸石咪唑酯骨架-8 (ZIF-8) 以通过释放 Zn 离子实现灭菌，以及通过均匀掺杂到其骨架中的 Mn 离子的可变价态来调节炎症。在这种简单的金属有机骨架 (MOF) 结构设计中，Mn-ZIF-8 具有 Mn ²⁺ /Mn ^{4+ 的}共存性赋予纳米复合材料抗炎能力，可通过氧化还原环境进行调节。Mn离子的酶活性与ZIF-8孔结构的优越性有效结合，通过反应物分子大小和高效内催化性能实现底物选择。通过这样的设计，这种纳米复合材料不仅对病原菌表现出优异的抗菌性能，而且通过调节巨噬细胞极化来抑制过度反应的炎症来重塑炎症免疫，从而在动物模型中对细菌感染的伤口愈合产生有利的治疗效果. 总之，该纳米平台提供了有效的方法，通过杀死细菌和调节炎症来加速受感染的伤口愈合，

更新日期：2021-11-17

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