Ocular Immunology and Inflammation ( IF 2.6 ) Pub Date : 2021-09-24 , DOI: 10.1080/09273948.2021.1976221 Xin Le Ng 1 , Bjorn Kaijun Betzler 2 , Ilaria Testi 3 , Su Ling Ho 1 , Melissa Tien 1 , Wei Kiong Ngo 1 , Manfred Zierhut 4 , Soon Phaik Chee 5, 6, 7 , Vishali Gupta 8 , Carlos E Pavesio 2 , Marc D de Smet 9, 10 , Rupesh Agrawal 1, 2, 5, 6, 7, 11
ABSTRACT
Purpose
The COVID-19 pandemic has galvanized the development of new vaccines at an unprecedented pace. Since the widespread implementation of vaccination campaigns, reports of ocular adverse effects after COVID-19 vaccinations have emerged. This review summarizes ocular adverse effects possibly associated with COVID-19 vaccination, and discusses their clinical characteristics and management.
Methods
Narrative Literature Review.
Results
Ocular adverse effects of COVID-19 vaccinations include facial nerve palsy, abducens nerve palsy, acute macular neuroretinopathy, central serous retinopathy, thrombosis, uveitis, multiple evanescent white dot syndrome, Vogt-Koyanagi-Harada disease reactivation, and new-onset Graves’ Disease. Studies in current literature are primarily retrospective case series or isolated case reports – these are inherently weak in establishing association or causality. Nevertheless, the described presentations resemble the reported ocular manifestations of the COVID-19 disease itself. Hence, we hypothesize that the human body’s immune response to COVID-19 vaccinations may be involved in the pathogenesis of the ocular adverse effects post-COVID-19 vaccination.
Conclusion
Ophthalmologists and generalists should be aware of the possible, albeit rare, ocular adverse effects after COVID-19 vaccination.
中文翻译:
接种 COVID-19 疫苗后的眼部不良事件
抽象的
目的
COVID-19 大流行以前所未有的速度刺激了新疫苗的开发。自广泛开展疫苗接种活动以来,关于接种 COVID-19 疫苗后出现眼部不良反应的报告不断出现。本综述总结了可能与 COVID-19 疫苗接种相关的眼部不良反应,并讨论了其临床特征和管理。
方法
叙事文献评论。
结果
COVID-19疫苗接种的眼部不良反应包括面神经麻痹、外展神经麻痹、急性黄斑神经视网膜病变、中心性浆液性视网膜病变、血栓形成、葡萄膜炎、多发性消失白点综合征、沃格特-小柳-原田病再激活和新发格雷夫斯病。当前文献中的研究主要是回顾性病例系列或孤立的病例报告——这些在建立关联或因果关系方面本质上是薄弱的。尽管如此,所描述的表现与报道的 COVID-19 疾病本身的眼部表现相似。因此,我们假设人体对 COVID-19 疫苗接种的免疫反应可能参与了 COVID-19 疫苗接种后眼部不良反应的发病机制。
结论
眼科医生和全科医生应意识到接种 COVID-19 疫苗后可能出现的眼部不良反应(尽管罕见)。