Voxel-based morphometry (VBM) studies of gray matter volume (GMV) in psychopathy have produced inconsistent results and few have been replicated. Therefore, to clarify GMV abnormalities associated with psychopathy as operationalized by Hare (2003), we conducted a meta-analysis of VBM studies using both categorical and dimensional analyses. We identified seven studies eligible for the categorical meta-analysis (136 men with psychopathy vs 150 male controls) and 11 studies (N = 519) eligible for dimensional metaregressions. First, we used seed-based d mapping with permutation of subject images for voxel-based meta-analyses. Statistical parametric maps of GMV were available for four (57%) of the studies included in the categorical meta-analysis and for five (45%) of the studies included in the dimensional metaregression analyses, with peak coordinates available for the remaining studies. Second, we used metadata of a large-scale neuroimaging database to provide an objective and quantitative account of psychological processes attributed to the brain regions we identified in our group meta-analysis and metaregressions. Men with psychopathy exhibited reliable GMV abnormalities circumscribed to the left hemisphere in the dorsolateral prefrontal cortex and the medial orbitofrontal cortex. Total psychopathy scores and Factors 1 and 2 scores were all related to decreased GMV within those two prefrontal regions, as well as decreased GMV in a wider set of regions encompassing midline, temporal, parietal, occipital, and subcortical structures. We discuss how decreased GMV in those regions likely account for the impairments in the emotion, cognition, action, and perception domains seen in the disorder. (PsycInfo Database Record (c) 2021 APA, all rights reserved).

中文翻译：

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精神病中的皮质和皮质下灰质体积：体素元分析。

精神病患者灰质体积 (GMV) 的基于体素的形态测量 (VBM) 研究产生了不一致的结果，并且很少被复制。因此，为了阐明 Hare (2003) 实施的与精神病相关的 GMV 异常，我们使用分类和维度分析对 VBM 研究进行了荟萃分析。我们确定了七项符合分类荟萃分析的研究（136 名患有精神病的男性与 150 名男性对照组）和 11 项符合维度元回归的研究（N = 519）。首先，我们使用基于种子的 d 映射和对象图像的排列进行基于体素的元分析。GMV 的统计参数图可用于分类荟萃分析中的四项 (57%) 研究和维度元回归分析中的五项 (45%) 研究，峰坐标可用于剩余的研究。其次，我们使用大规模神经影像数据库的元数据，对归因于我们在小组元分析和元回归中确定的大脑区域的心理过程提供客观和定量的解释。患有精神病的男性表现出可靠的 GMV 异常，局限于背外侧前额叶皮层和内侧眶额叶皮层的左半球。总精神病评分和因素 1 和因素 2 评分都与这两个前额叶区域的 GMV 降低有关，以及包括中线、颞叶、顶叶、枕叶和皮层下结构在内的更广泛区域的 GMV 降低。我们讨论了这些区域的 GMV 下降如何可能导致情绪、认知、行动、和感知域中看到的障碍。（PsycInfo 数据库记录 (c) 2021 APA，保留所有权利）。