We tested the hypotheses that female adolescents at risk for future eating disorders, based on parental history of binge eating and compensatory weight control behaviors, would show greater reward and attention region response to thin-models and tastes, anticipated tastes, and images of high-calorie foods, lower inhibitory circuitry response to a high-calorie food-specific go/no-go paradigm, and greater limbic circuitry response to negative mood induction. We recruited female adolescents free of binge eating or compensatory behaviors (N = 88; Mage = 14.6 [SD = .9]; 72% White) with versus without parental history of eating pathology. Parental-history-positive youth showed elevated reward region response (putamen) to anticipated tastes of chocolate milkshake, and greater emotionality, caloric deprivation, weight and shape overvaluation, and feeling fat (though no difference in weight), but lower liking of high-calorie foods, which were medium to large effects. We did not observe statistically significant differences in neural responsivity for the other paradigms. The evidence that parental-history-positive youth show greater reward region response to anticipated tastes of high-calorie food, overvaluation of weight/shape, feeling fat, caloric deprivation, emotionality, and lower liking of high-calorie foods before evidencing behavioral symptoms of eating disorders are novel findings. Weight/shape overvaluation may contribute to feeling fat, lower food liking, and caloric deprivation; the latter may drive elevated reward region response to anticipated consumption of high-calorie food and emotionality. (PsycInfo Database Record (c) 2021 APA, all rights reserved).

中文翻译：

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比较有和没有父母饮食病理史的健康青春期女性对食物和瘦模型的神经反应性以及其他潜在风险因素。

我们测试了以下假设：基于父母暴食史和补偿性体重控制行为，有未来饮食失调风险的女性青少年会对瘦模型和口味、预期口味和高卡路里食物，对高卡路里食物特定的去/不去范式的抑制电路反应较低，以及对消极情绪诱导的边缘电路反应较大。我们招募了没有暴饮暴食或补偿行为的女性青少年（N = 88；Mage = 14.6 [SD = .9]；72% 白人）有与没有父母饮食病理史。有父母史的年轻人对巧克力奶昔的预期口味表现出更高的奖励区域反应（壳核），以及更大的情绪、热量剥夺、体重和体型高估，和感觉脂肪（虽然体重没有差异），但不喜欢高热量食物，这是中到大的影响。对于其他范式，我们没有观察到神经反应性的统计学显着差异。有证据表明，父母历史阳性的青少年对高热量食物的预期口味、体重/体型的高估、感觉肥胖、热量缺乏、情绪化以及在证明行为症状之前对高热量食物的喜好度较低，表现出更大的奖励区域反应饮食失调是新发现。体重/体型高估可能会导致感觉肥胖、对食物的喜好降低和热量缺乏；后者可能会推动对高热量食物和情绪的预期消费的奖励区域反应升高。（PsycInfo 数据库记录 (c) 2021 APA，保留所有权利）。