Curcumin has been demonstrated to be an anti-tumor agent in many types of cancers, including gastric cancer (GC). However, the molecular mechanisms by which curcumin performs its anti-tumor effects remain elusive. circ_0056618 and miR-194-5p are reported to be involved in GC progression, but their relationships with curcumin are unclear. In this study, circ_0056618 was elevated, and miR-194-5p was reduced in GC tissues and cells. Curcumin treatment led to a decrease in circ_0056618 level in GC cells. Overexpression of circ_0056618 promoted cell proliferation, migration, and invasion and suppressed cell cycle arrest and apoptosis in curcumin-treated GC cells. Moreover, miR-194-5p was identified as the target of circ_0056618, and its expression in GC cells increased after curcumin treatment. Overexpression of miR-194-5p reversed the promotional effect of circ_0056618 on cell progression in curcumin-treated GC cells. Additionally, curcumin treatment repressed the tumorigenesis of GC in vivo through regulating circ_0056618. Curcumin treatment delayed the development of GC partly through decreasing circ_0056618 and increasing miR-194-5p.

中文翻译：

---

姜黄素通过调控circ_0056618/miR-194-5p轴抑制胃癌进展

姜黄素已被证明是多种癌症的抗肿瘤剂，包括胃癌 (GC)。然而，姜黄素发挥其抗肿瘤作用的分子机制仍然难以捉摸。据报道，circ_0056618 和 miR-194-5p 参与了 GC 进展，但它们与姜黄素的关系尚不清楚。在本研究中，在 GC 组织和细胞中，circ_0056618 升高，miR-194-5p 降低。姜黄素处理导致 GC 细胞中 circ_0056618 水平降低。circ_0056618 的过表达促进了姜黄素处理的 GC 细胞中的细胞增殖、迁移和侵袭，并抑制了细胞周期停滞和凋亡。此外，miR-194-5p 被确定为 circ_0056618 的靶标，姜黄素处理后其在 GC 细胞中的表达增加。miR-194-5p 的过表达逆转了 circ_0056618 对姜黄素处理的 GC 细胞中细胞进展的促进作用。此外，姜黄素治疗抑制了 GC 的肿瘤发生体内通过调节circ_0056618。姜黄素处理部分通过减少 circ_0056618 和增加 miR-194-5p 来延迟 GC 的发展。