This research aimed to describe the functions of vascular endothelial cells (VECs) in protecting target organs and the anti-atherosclerotic effects of different enantiomers of amlodipine on a rabbit model of atherosclerosis. Thirty male New Zealand white rabbits were randomly allocated to four groups (nA = 9, nB = 7, nC = 7, and nD = 7 rabbits): rabbits in group-A (control group) were fed a high-fat diet, group-B rabbits were fed a high-fat diet plus 2.5 mg/kg/day S-amlodipine, group-C rabbits were fed a high-fat diet plus 2.5 mg/kg/day R-amlodipine, and group-D rabbits were fed a high-fat diet plus 5 mg/kg/day racemic amlodipine. Different enantiomers of amlodipine did not influence lipid profiles and serum level of eNOS in the rabbit atherosclerosis model but decreased ET-1 expression to some extent. The serum NO and iNOS levels in the drug intervention groups were significantly reduced. No significant differences in the rabbits’ body weights were observed. At the 4th and 8th weeks, the serum lipid profiles significantly increased in high cholesterol diet groups. The serum ET-1 level was significantly increased in each group of rabbits at the 8th week. Both S-amlodipine and R-amlodipine may protect the endothelium by reducing the serum ET-1 level, downregulating iNOS expression.

中文翻译：

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氨氯地平不同对映体对动脉粥样硬化兔血脂和血管舒缩因子的影响

本研究旨在描述血管内皮细胞 (VECs) 保护靶器官的功能以及氨氯地平不同对映异构体对兔动脉粥样硬化模型的抗动脉粥样硬化作用。将 30 只雄性新西兰大白兔随机分为四组（nA = 9、nB = 7、nC = 7 和 nD = 7 只兔子）：A 组（对照组）的兔子喂食高脂饮食，组-B 组兔饲喂高脂饮食加 2.5 mg/kg/天 S-氨氯地平，C 组兔饲喂高脂饮食加 2.5 mg/kg/日 R-氨氯地平，D 组兔饲喂高脂肪饮食加 5 mg/kg/天消旋氨氯地平。氨氯地平的不同对映异构体不影响兔动脉粥样硬化模型中的脂质谱和血清eNOS水平，但在一定程度上降低了ET-1的表达。药物干预组血清NO和iNOS水平显着降低。没有观察到兔子体重的显着差异。在第 4 周和第 8 周，高胆固醇饮食组的血脂谱显着增加。第8周各组兔血清ET-1水平明显升高。S-氨氯地平和 R-氨氯地平都可以通过降低血清 ET-1 水平、下调 iNOS 表达来保护内皮细胞。