The significant function of circRNAs in cancer was recognized in recent work, so a well-organized resource is required for characterizing the interactions between circRNAs and other functional molecules (such as microRNA and RNA-binding protein) in cancer. We previously developed cancer-specific circRNA database (CSCD), a comprehensive database for cancer-specific circRNAs, which is widely used in circRNA research. Here, we updated CSCD to CSCD2 (http://geneyun.net/CSCD2 or http://gb.whu.edu.cn/CSCD2), which includes significantly more cancer-specific circRNAs identified from a large number of human cancer and normal tissues/cell lines. CSCD2 contains >1000 samples (825 tissues and 288 cell lines) and identifies a large number of circRNAs: 1 013 461 cancer-specific circRNAs, 1 533 704 circRNAs from only normal samples and 354 422 circRNAs from both cancer and normal samples. In addition, CSCD2 predicts potential miRNA–circRNA and RBP–circRNA interactions using binding motifs from >200 RBPs and 2000 microRNAs. Furthermore, the potential full-length and open reading frame sequence of these circRNAs were also predicted. Collectively, CSCD2 provides a significantly enhanced resource for exploring the function and regulation of circRNAs in cancer.

中文翻译：

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CSCD2：癌症特异性环状 RNA 的综合交互数据库

circRNAs 在癌症中的重要功能在最近的工作中得到认可，因此需要一个组织良好的资源来表征 circRNAs 与癌症中其他功能分子（如 microRNA 和 RNA 结合蛋白）之间的相互作用。我们之前开发了癌症特异性 circRNA 数据库 (CSCD)，这是一个癌症特异性 circRNA 的综合数据库，广泛用于 circRNA 研究。在这里，我们将 CSCD 更新为 CSCD2（http://geneyun.net/CSCD2 或 http://gb.whu.edu.cn/CSCD2），其中包括从大量人类癌症和正常组织/细胞系。CSCD2 包含超过 1000 个样本（825 个组织和 288 个细胞系）并识别大量 circRNA：1 013 461 个癌症特异性 circRNA，仅来自正常样本的 1 533 704 个 circRNA 和来自癌症和正常样本的 354 422 个 circRNA。此外，CSCD2 使用来自大于 200 个 RBP 和 2000 个 microRNA 的结合基序预测潜在的 miRNA-circRNA 和 RBP-circRNA 相互作用。此外，还预测了这些 circRNA 的潜在全长和开放阅读框序列。总的来说，CSCD2 为探索 circRNA 在癌症中的功能和调控提供了显着增强的资源。