BACKGROUND The relationship between allergic individuals and their responsiveness to routine vaccines has rarely been investigated. This study examined whether the seroprevalence of measles antibody differed between children with and without allergic diseases in the general pediatric population. METHODS The cross-sectional study was performed within a prospective general birth cohort (a pilot study of the Japan Environment & Children's Pilot Study [JECS]) of children aged 8 years. The clinical history of allergic diseases, measles, and the concentration of measles immunoglobulin G titers in serum enzyme immunoassay were examined. Fisher's exact tests were used to assess the relationships between the allergic characteristics of the children and their measles antibody positivity rates. RESULTS This study included 162 children. Any allergic disease was reported in 75 (46.3%). The measles antibody positivity rate was 94.7% among children with any allergic diseases and 92.0% among children without allergic diseases. Our results revealed no differences in measles antibody seropositivity between children with allergies and controls. CONCLUSIONS Children with allergies mount and maintain a comparable immune response to the measles vaccine.

中文翻译：

---

过敏性疾病儿童中的麻疹抗体血清阳性：日本环境与儿童试点研究中的一项横断面研究。


背景过敏个体与其对常规疫苗的反应之间的关系很少被研究。这项研究调查了一般儿科人群中患有和不患有过敏性疾病的儿童之间麻疹抗体的血清阳性率是否存在差异。方法 这项横断面研究是在 8 岁儿童的前瞻性一般出生队列（日本环境与儿童试点研究 [JECS] 的一项试点研究）中进行的。检查过敏性疾病、麻疹临床病史以及血清酶联免疫分析中麻疹免疫球蛋白G滴度浓度。费希尔精确测试用于评估儿童的过敏特征与其麻疹抗体阳性率之间的关系。结果 这项研究包括 162 名儿童。 75 人（46.3%）报告有任何过敏性疾病。有过敏性疾病儿童麻疹抗体阳性率为94.7%，无过敏性疾病儿童麻疹抗体阳性率为92.0%。我们的结果显示，过敏儿童和对照儿童之间的麻疹抗体血清阳性率没有差异。结论 过敏儿童对麻疹疫苗产生并维持相当的免疫反应。