Background and Objective: Today, a new β-coronavirus called SARS-CoV-2 has emerged and it is causing a global pandemic. Inter-human transmission studies have indicated a significant role of aerosols in the transmission of many respiratory viruses. Hence, it is very important to decrease the spread of the virus through disinfectant agents. This review aimed to provide an overview related to possible alternative inhibitory molecules against this virus.

Method: The literature search was performed in the MEDLINE electronic database using the public access known as NCBI-PUBMED. Keywords "coronavirus" and “SARS-CoV-2” and “COVID19” were used. No specific time range was used.

Results: We provide a review related to structure, anti-coronavirus activity and molecular mechanism of natural substances and semisynthetic derivatives such as glycopeptides, lipopeptides, probiotics, surfactants, terpenes and resveratrol. We also include the latest in vitro experiments with anti-SARSCoV- 2 activity. We also provide the theoretical basis for discussing the prospects of such natural molecules as possible alternative anti-Coronavirus products, so as to develop a complete screening for future applications.

Conclusion: In summary, this review suggest to investigate deeper several molecules most of which belong to natural substances to fight COVID19 disease.

背景与目的：今天，一种名为 SARS-CoV-2 的新型 β 冠状病毒已经出现，并正在引起全球大流行。人际传播研究表明，气溶胶在许多呼吸道病毒的传播中起着重要作用。因此，通过消毒剂减少病毒的传播非常重要。本综述旨在提供与可能的针对该病毒的替代抑制分子相关的概述。

方法：使用称为 NCBI-PUBMED 的公共访问在 MEDLINE 电子数据库中进行文献检索。使用了关键词“冠状病毒”和“SARS-CoV-2”和“COVID19”。没有使用特定的时间范围。

结果：我们对天然物质和半合成衍生物（如糖肽、脂肽、益生菌、表面活性剂、萜烯和白藜芦醇）的结构、抗冠状病毒活性和分子机制进行了综述。我们还包括具有抗 SARSCoV-2 活性的最新体外实验。我们还为讨论此类天然分子作为可能的替代抗冠状病毒产品的前景提供了理论基础，从而为未来的应用开发了完整的筛选。

结论：总而言之，本综述建议更深入地研究几种分子，其中大部分属于天然物质，以对抗 COVID19 疾病。