Background: Metal-organic frameworks (MOFs) possess adjustable aperture, high load capacities, tailorable structures, and excellent biocompatibilities for their use as drug delivery carries in cancer therapy. Until now, Zr-MOFs, in particular, combine optimal stability towards hydrolysis and post synthetic modification with low toxicity, and are widely studied for their excellentbiological performance.

Introduction: This review comprises the exploration of Zr-MOFs as drug delivery devices (DDSs) with a focus on various new methods, including chemotherapy (CT), photodynamic therapy (PDT), photothermal therapy (PTT), sonodynamic therapy (SDT), radiotherapy, immunotherapy, gene therapy and related combined therapies, which all generate reactive oxygen species (ROS) to achieve high efficiency of tumor therapy.

Conclusion: We described and summarized these pertinent examples of the therapeutic mechanisms and highlighted the antitumor effects of their biological application both in vitro and in vivo. The perspectives on their future applications and the analogous challenge of the Zr-MOFs materials are given.

背景：金属有机框架 (MOF) 具有可调节的孔径、高负载能力、可定制的结构和出色的生物相容性，可用作癌症治疗中的药物输送载体。迄今为止，特别是 Zr-MOFs 结合了对水解和合成后修饰的最佳稳定性和低毒性，并因其优异的生物学性能而被广泛研究。

简介：这篇综述包括探索 Zr-MOFs 作为药物递送装置 (DDSs)，重点关注各种新方法，包括化学疗法 (CT)、光动力疗法 (PDT)、光热疗法 (PTT)、声动力疗法 (SDT)、放疗、免疫治疗、基因治疗及相关联合治疗，均产生活性氧（ROS），实现肿瘤治疗的高效化。

结论：我们描述和总结了这些治疗机制的相关例子，并强调了它们在体外和体内生物应用的抗肿瘤作用。给出了它们未来应用的前景以及 Zr-MOFs 材料的类似挑战。