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A Review on Rotenoids: Purification, Characterization and its Biological Applications
Mini-Reviews in Medicinal Chemistry ( IF 3.3 ) Pub Date : 2021-07-31 , DOI: 10.2174/1389557521666210217092634
Praveen Kumar P K 1 , Priyadharshini A 1 , Sivanandham Muthukumaran 1
Affiliation  

Phytochemicals play a vital role as drugs for the treatment of various autoimmune, viral, and cancerous diseases. Rotenoids, a type of isoflavone compounds present in plants genus Boerhaavia sp., Mirabilis sp. and Abronia sp. which belong to the Nyctaginaceae family, are traditionally used as pesticides and insecticides. Boeravinones are groups of rotenoid compounds widely used as drugs or drug adjuvants for the treatment of various diseases. Extraction of rotenoids in various solvents, purification of rotenoids in various chromatographic technique studies, and the characterization of functional groups of rotenoids in various spectroscopic techniques have been reported. Biological applications of rotenoids such as anti-cancerous, antioxidant, anti-inflammatory, antimicrobial, and cytotoxic activities have been discussed. This review summarizes the extraction, isolation, purification, and characterization of rotenoid compounds and their effect on the treatment of cancer, inflammatory, spasmolytic, autoimmune, and microbial diseases.



中文翻译:

类胡萝卜素综述:纯化、表征及其生物学应用

植物化学物质作为治疗各种自身免疫性疾病、病毒性疾病和癌症疾病的药物起着至关重要的作用。Rotenoids,一种存在于植物 Boerhaavia sp., Mirabilis sp. 中的异黄酮化合物。和 Abronia sp。属于 Nyctaginaceae 科,传统上用作杀虫剂和杀虫剂。Boeravinones是一类广泛用作治疗各种疾病的药物或药物佐剂的类胡萝卜素化合物。已经报道了在各种溶剂中提取类胡萝卜素、在各种色谱技术研究中纯化类胡萝卜素以及在各种光谱技术中表征类胡萝卜素的官能团。已经讨论了类胡萝卜素的生物应用,例如抗癌、抗氧化、抗炎、抗菌和细胞毒活性。

更新日期:2021-09-23
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