The normal function of the mitochondria is crucial for most tissues especially for those that demand a high energy supply. Emerging evidence has pointed out that healthy mitochondrial function is closely associated with normal heart function. When these processes fail to repair the damaged mitochondria, cells initiate a removal process referred to as mitophagy to clear away defective mitochondria. In cardiomyocytes, mitophagy is closely associated with metabolic activity, cell differentiation, apoptosis, and other physiological processes involved in major phenotypic alterations. Mitophagy alterations may contribute to detrimental or beneficial effects in a multitude of cardiac diseases, indicating potential clinical insights after a close understanding of the mechanisms. Here, we discuss the current opinions of mitophagy in the progression of cardiac diseases, such as ischemic heart disease, diabetic cardiomyopathy, cardiac hypertrophy, heart failure, and arrhythmia, and focus on the key molecules and related pathways involved in the regulation of mitophagy. We also discuss recently reported approaches targeting mitophagy in the therapy of cardiac diseases.

中文翻译：

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线粒体自噬在心脏中的新作用：调节线粒体自噬在心脏病中的治疗潜力


线粒体的正常功能对于大多数组织尤其是那些需要高能量供应的组织至关重要。新的证据指出，健康的线粒体功能与正常的心脏功能密切相关。当这些过程无法修复受损的线粒体时，细胞会启动称为线粒体自噬的清除过程，以清除有缺陷的线粒体。在心肌细胞中，线粒体自噬与代谢活动、细胞分化、细胞凋亡以及涉及主要表型改变的其他生理过程密切相关。线粒体自噬的改变可能会对多种心脏病产生有害或有益的影响，这表明在仔细了解其机制后可能会产生潜在的临床见解。在此，我们讨论目前关于线粒体自噬在缺血性心脏病、糖尿病心肌病、心脏肥大、心力衰竭和心律失常等心脏病进展中的观点，并重点讨论参与线粒体自噬调控的关键分子和相关通路。我们还讨论了最近报道的针对线粒体自噬治疗心脏病的方法。