Ferritin heavy chain (FTH1) exerts significant antigrowth effects in breast cancer cells by inhibiting the expression of c-MYC,FEBS Open Bio

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Ferritin heavy chain (FTH1) exerts significant antigrowth effects in breast cancer cells by inhibiting the expression of c-MYC
FEBS Open Bio ( IF 2.8 ) Pub Date : 2021-09-22 , DOI: 10.1002/2211-5463.13303
Amjad Ali ₁ , Jasmin Shafarin ₁ , Rola Abu Jabal ₂ , Nour Aljabi ₂ , Mohamad Hamad _{1,

3} , Jibran Sualeh Muhammad _{1,

2} , Hema Unnikannan ₁ , Mawieh Hamad _{1,

3}

Affiliation

Overexpression of ferritin heavy chain (FTH1) often associates with good prognosis in breast cancer (BCa), particularly in the triple-negative subtype (triple-negative breast cancer). However, the mechanism by which FTH1 exerts its possible tumor suppressor effects in BCa is not known. Here, we examined the bearing of FTH1 silencing or overexpression on several aspects of BCa cell growth in vitro. FTH1 silencing promoted cell growth and mammosphere formation, increased c-MYC expression, and reduced cell sensitivity to chemotherapy. In contrast, FTH1 overexpression inhibited cell growth, decreased c-MYC expression, and sensitized cancer cells to chemotherapy; silencing of c-MYC recapitulated the effects of FTH1 overexpression. These findings show for the first time that FTH1 suppresses tumor growth by inhibiting the expression of key oncogenes, such as c-MYC.

中文翻译：

铁蛋白重链 (FTH1) 通过抑制 c-MYC 的表达在乳腺癌细胞中发挥显着的抗生长作用

铁蛋白重链 ( FTH1 ) 的过表达通常与乳腺癌 (BCa) 的良好预后相关，特别是在三阴性亚型（三阴性乳腺癌）中。然而，FTH1在 BCa 中发挥其可能的肿瘤抑制作用的机制尚不清楚。在这里，我们检查了FTH1沉默或过表达对 BCa 细胞体外生长的几个方面的影响。FTH1沉默促进细胞生长和乳腺球形成，增加c-MYC表达，并降低细胞对化疗的敏感性。相比之下，FTH1过表达抑制细胞生长，降低 c-MYC 表达，并使癌细胞对化疗敏感；c-MYC的沉默概括了FTH1过表达的影响。这些发现首次表明FTH1通过抑制关键癌基因（如c-MYC ）的表达来抑制肿瘤生长。

更新日期：2021-11-03

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