The adenine N⁶-methylation m⁶A is a crucial modification that is associated with several biological functions. One of the two m⁶A demethylases FTO has arisen as an attractive target for the development of novel cancer therapies. Here, we describe a new design, synthesis and evaluation of a photo-responsive and selective inhibitor of FTO.

中文翻译：

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m6A RNA 去甲基化酶 FTO 的光响应化学调节

腺嘌呤N ⁶ -甲基化 m ⁶ A 是与多种生物学功能相关的关键修饰。两种 m ⁶ A 脱甲基酶 FTO 中的一种已成为开发新型癌症疗法的有吸引力的目标。在这里，我们描述了一种光响应性和选择性 FTO 抑制剂的新设计、合成和评估。