Ruthenium(II)-catalyzed C–H activation and (4+2) annulation of aromatic hydroxamic acid esters with allylic amides,Chemical Communications

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Ruthenium(II)-catalyzed C–H activation and (4+2) annulation of aromatic hydroxamic acid esters with allylic amides
Chemical Communications ( IF 4.3 ) Pub Date : 2021-09-14 , DOI: 10.1039/d1cc04422b
Chandan Kumar Giri ₁ , Suman Dana ₁ , Mahiuddin Baidya ₁

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A (4+2) annulation under Ru(II)-catalysis is reported using aromatic hydroxamic acid esters as the oxidizing directing group and allylic amides as unactivated olefin coupling partners, delivering a wide variety of aminomethyl isoquinolinones in good to excellent yields. This annulation is distinctive as allylic congeners typically result in allylation and not the annulation. Late-stage derivatization of a bioactive synthetic bile acid has been showcased.

中文翻译：

钌 (II) 催化的 C-H 活化和芳香异羟肟酸酯与烯丙酰胺的 (4+2) 环化

据报道，在 Ru( II ) 催化下的 (4+2) 环化使用芳族异羟肟酸酯作为氧化导向基团，烯丙基酰胺作为未活化的烯烃偶联伙伴，以良好到优异的产率提供各种氨甲基异喹啉酮。这种环化是独特的，因为烯丙基同类物通常导致烯丙基化而不是环化。已经展示了生物活性合成胆汁酸的后期衍生化。

更新日期：2021-09-23

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