Assessment of Quality of Life 8-Dimension (AQoL-8D): translation, validation, and application in two Dutch trials in patients with epilepsy and schizophrenia,Expert Review of Pharmacoeconomics & Outcomes Research

当前位置： X-MOL 学术 › Expert Rev. Pharmacoecon. Outcomes Res. › 论文详情

Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)

Assessment of Quality of Life 8-Dimension (AQoL-8D): translation, validation, and application in two Dutch trials in patients with epilepsy and schizophrenia
Expert Review of Pharmacoeconomics & Outcomes Research ( IF 1.8 ) Pub Date : 2021-09-26 , DOI: 10.1080/14737167.2021.1981861
Hoi Yau Chan ₁ , Ben F M Wijnen _{1,

2} , Mickaël Hiligsmann ₁ , Filip Smit _{3,

4} , Loes A M Leenen _{1,

2} , Marian H J M Majoie _{2,

5,

6,

7} , Silvia M A A Evers _{1,

3}

Affiliation

ABSTRACT

Background

To translate and linguistically validate the Assessment of Quality of Life 8-dimensions (AQoL-8D) for use in the Netherlands and to compare the psychometric properties of AQoL-8D with the EuroQol 5-dimensions 5-levels (EQ-5D-5L) in two patient samples.

Methods

AQoL-8D was translated from English into Dutch. The translated AQoL-8D was then administered alongside the EQ-5D-5L at baseline and follow-up of two Dutch randomized controlled trials among patients with epilepsy and schizophrenia. These data were subjected to a post-hoc analysis assessing the psychometric properties of AQol-8D vis-à-vis EQ-5D-5L in terms of known-groups construct validity, responsiveness, and floor/ceiling effects.

Results

In total, 103 epilepsy patients and 99 schizophrenia patients were included in this study. In both datasets, the two instruments discriminated between known-groups, but in schizophrenia, AQoL-8D showed higher responsiveness than EQ-5D-5L, while both instruments showed equal responsiveness in epilepsy. Ceiling effects were only found for EQ-5D-5L in both epilepsy (26.6%) and schizophrenia (6.1%).

Conclusion

Our results have shown that, among other things, AQoL-8D presents better ability to discriminate between known-groups and shows no ceiling effect. Based on our results, we would recommend the use of AQoL-8D in addition to EQ-5D-5L in trials assessing patient’s quality of life in patients with epilepsy or schizophrenia.

中文翻译：

生活质量 8 维 (AQoL-8D) 评估：在两项针对癫痫和精神分裂症患者的荷兰试验中的翻译、验证和应用

摘要

背景

翻译和语言验证 8 维生活质量评估 (AQoL-8D) 以供在荷兰使用，并将 AQoL-8D 的心理测量特性与 EuroQol 5 维 5 级 (EQ-5D-5L) 进行比较在两个患者样本中。

方法

AQoL-8D 从英语翻译成荷兰语。然后，翻译后的 AQoL-8D 在基线时与 EQ-5D-5L 一起使用，并在荷兰癫痫和精神分裂症患者中进行了两项随机对照试验的随访。对这些数据进行事后分析，评估 AQol-8D 与 EQ-5D-5L 在已知组结构有效性、响应性和地板/天花板效应方面的心理测量特性。

结果

本研究共纳入 103 名癫痫患者和 99 名精神分裂症患者。在这两个数据集中，这两种仪器在已知组之间进行了区分，但在精神分裂症中，AQoL-8D 显示出比 EQ-5D-5L 更高的响应性，而两种仪器在癫痫中显示出相同的响应性。仅在癫痫（26.6%）和精神分裂症（6.1%）中发现 EQ-5D-5L 的天花板效应。