Ferroptosis as a mechanism of neurodegeneration in Alzheimer's disease,Journal of Neurochemistry

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Ferroptosis as a mechanism of neurodegeneration in Alzheimer's disease
Journal of Neurochemistry ( IF 4.2 ) Pub Date : 2021-09-23 , DOI: 10.1111/jnc.15519
Md Jakaria ₁ , Abdel Ali Belaidi ₁ , Ashley I Bush ₁ , Scott Ayton ₁

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Alzheimer's disease (AD) is the most prevalent form of dementia, with complex pathophysiology that is not fully understood. While β-amyloid plaque and neurofibrillary tangles define the pathology of the disease, the mechanism of neurodegeneration is uncertain. Ferroptosis is an iron-mediated programmed cell death mechanism characterised by phospholipid peroxidation that has been observed in clinical AD samples. This review will outline the growing molecular and clinical evidence implicating ferroptosis in the pathogenesis of AD, with implications for disease-modifying therapies.

中文翻译：

铁死亡作为阿尔茨海默病神经退行性变的机制

阿尔茨海默病 (AD) 是最普遍的痴呆形式，其复杂的病理生理学尚未完全了解。虽然 β-淀粉样蛋白斑块和神经原纤维缠结定义了疾病的病理学，但神经变性的机制尚不确定。铁死亡是一种铁介导的程序性细胞死亡机制，其特征是在临床 AD 样本中观察到的磷脂过氧化。这篇综述将概述越来越多的分子和临床证据表明铁死亡与 AD 的发病机制有关，并对疾病缓解疗法产生影响。

更新日期：2021-11-27

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