ABSTRACT

Introduction

Lipid-based nano-drug delivery systems (LBNDDSs) have gained widespread attention in oral drug delivery due to their tunable and versatile properties such as biocompatibility and biodegradability, which makes them promising delivery systems for a variety of therapeutics. Currently, different types of LBNDDSs including liposomes, micelles, nanoemulsions, and solid lipid nanoparticles (SLNs) are developed for drug delivery applications. SLNs can be used as a controlled drug delivery system for oral delivery applications. However, its lipidic context makes that susceptible to lipolysis. The lipolysis rate of SLNs is affected by many factors that raise many questions for developing a more efficient delivery system

Areas covered

In the present work, we highlighted different factors affecting the digestion rate/level of SLNs in the gastrointestinal tract. This paper can be most useful for those researchers who are keen to develop a properly controlled drug delivery system based on SLNs for oral delivery applications.

Expert opinion

SLNs can be used as a controlled drug delivery system for oral delivery applications. However, its lipidic context makes that susceptible to lipolysis. The lipolysis rate of SLNs is affected by many factors that raise many questions for developing a more efficient delivery system.

中文翻译：

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固体脂质纳米粒的口服给药：强调影响脂解率的理化特性和生理条件

摘要

介绍

基于脂质的纳米药物递送系统（LBNDDS）由于其生物相容性和生物降解性等可调和通用的特性而在口服药物递送中受到广泛关注，这使它们成为用于各种治疗的有希望的递送系统。目前，开发了不同类型的 LBNDDS，包括脂质体、胶束、纳米乳液和固体脂质纳米颗粒 (SLN)，用于药物递送应用。SLN 可用作口服给药应用的受控给药系统。然而，它的脂质环境使其易于脂肪分解。SLN 的脂解率受到许多因素的影响，这些因素对开发更有效的输送系统提出了许多问题

覆盖区域

在目前的工作中，我们强调了影响胃肠道中 SLN 消化率/水平的不同因素。对于那些热衷于开发基于 SLN 的适当控制的药物输送系统用于口服输送应用的研究人员来说，本文可能是最有用的。

专家意见

SLN 可用作口服给药应用的受控给药系统。然而，它的脂质环境使其易于脂肪分解。SLN 的脂解率受许多因素的影响，这些因素对开发更有效的递送系统提出了许多问题。