Escape from nonsense mediated mRNA decay (NMD-) can produce activated or inactivated gene products, and bias in rates of escape can identify functionally important genes in germline disease. We hypothesized that the same would be true of cancer genes, and tested for NMD- bias within The Cancer Genome Atlas pan-cancer somatic mutation dataset. We identify 29 genes that show significantly elevated or suppressed rates of NMD-. This novel approach to cancer gene discovery reveals genes not previously cataloged as potentially tumorigenic, and identifies many potential driver mutations in known cancer genes for functional characterization.

中文翻译：

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选择或反对逃避无义介导的衰变是检测癌症基因的新特征

逃避无义介导的 mRNA 衰变 (NMD-) 可以产生激活或失活的基因产物，并且逃避率的偏差可以识别生殖系疾病中的功能重要基因。我们假设癌症基因也是如此，并在癌症基因组图谱泛癌体细胞突变数据集中测试了 NMD 偏差。我们确定了 29 个显示 NMD- 显着升高或抑制率的基因。这种癌症基因发现的新方法揭示了以前未归类为潜在致瘤基因的基因，并在已知癌症基因中鉴定了许多潜在的驱动突变以进行功能表征。