New labdanoid derivatives containing hydrophilic substituents (amino, methylamino) in the C-4 position were synthesized via selective transformations of lambertianic acid chloride. A one-pot method was proposed to prepare 16-formyllambertianic acid amide and included selective formylation of lambertianic acid by POCl₃ in DMF followed by amidation by aqueous NH₄OH. The molecular structure of the compound was studied by an X-ray crystal structure analysis. Analgesic activity in a chemical irritation model was found for newly synthesized 4-amino-18-nor-15,16-epoxylabda-8(17),13,14-triene and 4-(pyrrolidin-1-yl)-18-nor-15,16-epoxylabda-8(17),13,14-triene oxalates and 16-hydroxymethyl)lambertianic acid amide.

通过朗伯坦酰氯的选择性转化，合成了在 C-4 位含有亲水性取代基（氨基、甲氨基）的新型劳丹脂衍生物。提出了一种一锅法来制备 16-甲酰基琥珀酸酰胺，包括在 DMF中通过 POCl ₃对朗伯酸进行选择性甲酰化，然后通过 NH ₄ OH水溶液进行酰胺化。通过X射线晶体结构分析研究了该化合物的分子结构。在化学刺激模型中发现了新合成的 4-amino-18-nor-15,16-epoxylabda-8(17),13,14-triene 和 4-(pyrrolidin-1-yl)-18-nor 的镇痛活性-15,16-epoxylabda-8(17),13,14-triene 草酸盐和 16-羟甲基)lambertianic 酰胺。