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Helix-Constrained Peptides Constructed by Head-to-Side Chain Cross-Linking Strategies
Organic Letters ( IF 4.9 ) Pub Date : 2021-09-22 , DOI: 10.1021/acs.orglett.1c02820
Xiao-Xu Chen 1 , Yang Tang 2 , Meng Wu 1 , Yan-Ni Zhang 1 , Kai Chen 1 , Zhaocai Zhou 3 , Ge-Min Fang 1
Affiliation  

Facile head-to-side chain cross-linking strategies are developed to generate helix-constrained peptides. In our strategies, a covalent cross-linker is incorporated at N, i+7 or N, i+1 positions to lock the peptide into a helical conformation. The described patterns of head-to-side chain cross-linking will provide new frameworks for constrained helical peptide.

中文翻译:

头对侧链交联策略构建的螺旋约束肽

开发了简便的头侧链交联策略来生成螺旋约束肽。在我们的策略中,共价交联剂掺入 N, i+7 或 N, i+1 位置以将肽锁定为螺旋构象。所描述的头侧链交联模式将为受限螺旋肽提供新的框架。
更新日期:2021-10-15
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