当前位置: X-MOL 学术Trends Neurosci. › 论文详情
Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)
Neuronal pericellular baskets: neurotransmitter convergence and regulation of network excitability
Trends in Neurosciences ( IF 14.6 ) Pub Date : 2021-09-23 , DOI: 10.1016/j.tins.2021.08.006
Rebecca A Senft 1 , Susan M Dymecki 1
Affiliation  

A pericellular basket is a presynaptic configuration of numerous axonal boutons outlining a target neuron soma and its proximal dendrites. Recent studies show neurochemical diversity of pericellular baskets and suggest that neurotransmitter usage together with the dense, soma-proximal boutons may permit strong input effects on different timescales. Here we review the development, distribution, neurochemical phenotypes, and possible functions of pericellular baskets. As an example, we highlight pericellular baskets formed by projections of certain Pet1/Fev neurons of the serotonergic raphe nuclei. We propose that pericellular baskets represent convergence sites of competition or facilitation between neurotransmitter systems on downstream circuitry, especially in limbic brain regions, where pericellular baskets are widespread. Study of these baskets may enhance our understanding of monoamine regulation of memory, social behavior, and brain oscillations.



中文翻译:


神经元细胞周篮:神经递质汇聚和网络兴奋性调节



细胞周篮是由许多轴突纽扣组成的突触前结构,勾勒出目标神经元胞体及其近端树突。最近的研究显示了细胞周篮的神经化学多样性,并表明神经递质的使用与密集的、体细胞近端的纽带可能会在不同的时间尺度上产生强烈的输入效应。在这里,我们回顾了细胞周篮的发育、分布、神经化学表型和可能的功能。作为一个例子,我们强调了由血清素能中缝核的某些Pet1/Fev神经元的投射形成的细胞周篮。我们认为细胞周篮代表下游回路上神经递质系统之间竞争或促进的汇聚位点,特别是在细胞周篮广泛分布的边缘脑区域。对这些篮子的研究可能会增强我们对单胺对记忆、社会行为和大脑振荡的调节的理解。

更新日期:2021-10-26
down
wechat
bug