Abstract

An efficient two-component domino reaction strategy has been developed for the synthesis of 2,6-dicyanoaniline and 3-amino-9,10-dihydrophenanthrene-2,4-dicarbonitrile derivatives in moderate to good yield by the reaction between malononitrile and β-chloro-α,β-unsaturated aldehydes catalyzed by potassium hydroxide-18-crown-6 in methanol. In-vitro intercalation studies of 3-amino-9,10-dihydrophenanthrene-2,4-dicarbonitriles with Calf-Thymus DNA have been carried out which reveal that the moiety interacts with an affinity greater than that of ethidium bromide (EtBr).

中文翻译：

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18-冠醚钾催化合成2,6-二氰基苯胺和3-氨基-9,10-二氢菲-2,4二甲腈及其对小牛胸腺DNA的体外嵌入研究

摘要

已开发出一种有效的双组分多米诺反应策略，用于通过丙二腈和 β- 反应以中等至良好的收率合成 2,6-二氰基苯胺和 3-氨基-9,10-二氢菲-2,4-二甲腈衍生物。由氢氧化钾-18-冠-6 在甲醇中催化的氯-α,β-不饱和醛。3-氨基-9,10-二氢菲-2,4-二甲腈与小牛胸腺 DNA的体外嵌入研究表明，该部分的相互作用比溴化乙锭 (EtBr) 的亲和力更大。