A highly sensitive and selective sensor is urgently needed in many practical H₂O₂ detection, such as water quality monitoring, quality control of food products, and so on. However, the traditional three electrode system limits its further development in recent years due to its difficulty in miniaturization and integration. To effectively improve its sensitivity and selectivity, highly-ordered TiO₂ nanotube arrays (TNTAs) are modified with Pt nanoparticles and Prussian blue (PB) nanotubes and creatively combines with thin-film transistor (TFT) based on ZnO to prepare an electrochemical sensor. The sensor uses PBNCs as recognition units for the specific detection of H₂O_2, and the generated electrical signal is amplified by TFT. Thus, a highly sensitive and selective H₂O₂ sensor is achieved. The detection limit of the sensor is as low as 5.19 nM, which is three orders of magnitude lower than the conventional electrochemical detection methods using the same electrode. The sensor also possesses wider linear detection range of 0.1–50 μM and 50 μM–5 mM comparable to that of other reported H₂O₂ sensors. Besides, the sensor has good selectivity for H₂O₂ in the presence of common interferences such as ascorbic acid, uric acid, glucose, and dopamine. Furthermore, the device presents good reproducibility and exhibits good long-term stability over 27 days of continuous measurement. This study offers important insights for the rational design of sensors with high sensitivity and selectivity.

许多实际的H ₂ O ₂检测，如水质监测、食品质量控制等，都迫切需要一种高灵敏度和选择性的传感器。然而，传统的三电极系统由于其小型化和集成化困难，限制了其近年来的进一步发展。为了有效提高其灵敏度和选择性，高度有序的TiO ₂纳米管阵列（TNTA）用Pt纳米颗粒和普鲁士蓝（PB）纳米管进行改性，并创造性地与基于ZnO的薄膜晶体管（TFT）结合制备电化学传感器。传感器使用PBNCs作为识别单元，专门检测H ₂ O _{2 ，}产生的电信号经TFT放大。因此，实现了高度灵敏和选择性的H ₂ O ₂传感器。该传感器的检测限低至5.19 nM，比使用相同电极的常规电化学检测方法低三个数量级。该传感器还具有 0.1–50 μM 和 50 μM–5 mM 的更宽线性检测范围，与其他报道的 H ₂ O ₂传感器相当。此外，该传感器对 H ₂ O ₂具有良好的选择性在存在常见干扰物（如抗坏血酸、尿酸、葡萄糖和多巴胺）的情况下。此外，该设备具有良好的重现性，并在 27 天的连续测量中表现出良好的长期稳定性。这项研究为合理设计具有高灵敏度和选择性的传感器提供了重要的见解。