Light-driven unidirectional molecular motors have gained significant attention since the pioneering work by Prof. Ben Feringa in 1999, and they hold great promise as next-generation smart materials. The intrinsic feature of point chirality and the helicity of these molecular motors requires efficient strategies to access their optically pure forms, especially when chirality-sensitive materials are fabricated. In this short review, we summarize synthetic strategies to access optically pure first- and second-generation molecular motors. Three general strategies are discussed: direct asymmetric synthesis, chiral auxiliary methods and chiral separation aided by a resolving agent. We hope that this review will ignite the enthusiasm of synthetic chemists to address very fundamental but unavoidable synthetic questions on chiral-alkene-based molecular motors concerning their large-scale appli­cations.1 Introduction2 Synthesis of First-Generation Molecular Motors2.1 Direct Asymmetric Synthesis of Molecular Motors2.2 Resolving-Agent-Aided Chiral Resolution of Molecular Motors3 Synthesis of Second-Generation Molecular Motors3.1 Direct Asymmetric Synthesis of Molecular Motors3.2 Chiral Auxiliary Strategy3.3 Domino Strategy4 onclusions

中文翻译：

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开发获得光学纯 Feringa 电机的合成策略

自 1999 年 Ben Feringa 教授的开创性工作以来，光驱动的单向分子马达受到了广泛的关注，它们作为下一代智能材料具有广阔的前景。点手性的内在特征和这些分子马达的螺旋性需要有效的策略来获得它们的光学纯形式，尤其是在制造手性敏感材料时。在这篇简短的评论中，我们总结了获得光学纯第一代和第二代分子马达的合成策略。讨论了三种一般策略：直接不对称合成、手性辅助方法和拆分剂辅助的手性分离。