Frontiers in Immunology ( IF 5.7 ) Pub Date : 2021-09-23 , DOI: 10.3389/fimmu.2021.726472 Aloysious Ssemaganda 1 , Francois Cholette 1, 2 , Michelle Perner 1 , Cheli Kambaran 1 , Wendy Adhiambo 3 , Peter M Wambugu 3 , Henok Gebrebrhan 1 , Amy Lee 1 , Faisal Nuhu 1 , Ruth S Mwatelah 1 , Naima Jahan 1 , Tosin E Omole 1 , Tabitha Wanjiru 3 , Apollo Gitau 3 , Joshua Kimani 1, 3 , Lyle R McKinnon 1, 2, 4
Regulatory T cells (Tregs) play important roles in tissue homeostasis, but few studies have investigated tissue Tregs in the context of genital inflammation, HIV target cell density, and vaginal microbiota in humans. In women from Nairobi (n=64), the proportion of CD4+ CD25+ CD127low Tregs in the endocervix correlated with those in blood (r=0.31, p=0.01), with a higher Treg frequency observed in the endocervix (median 3.8
中文翻译:
子宫颈管调节性 T 细胞与减少生殖器炎症和降低 HIV 靶细胞丰度有关
调节性 T 细胞 (Tregs) 在组织稳态中发挥重要作用,但很少有研究在人类生殖器炎症、HIV 靶细胞密度和阴道微生物群的背景下研究组织 Tregs。在来自内罗毕的女性 (n=64) 中,子宫颈内膜中 CD4+ CD25+ CD127低Treg的比例与血液中的相关 (r=0.31, p=0.01),在子宫颈内观察到的 Treg 频率更高(中位数 3.8