当前位置: X-MOL 学术Allergy › 论文详情
Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)
Coordinated IgG2 and IgE responses as a marker of allergen immunotherapy efficacy
Allergy ( IF 12.6 ) Pub Date : 2021-09-22 , DOI: 10.1111/all.15107
Véronique Bordas-Le Floch 1 , Nathalie Berjont 1 , Thierry Batard 1 , Nirupama Varese 2, 3 , Robyn E O'Hehir 2, 3 , Walter G Canonica 4, 5 , Menno C van Zelm 2, 3 , Laurent Mascarell 1
Affiliation  

IgG2 responses are associated with repeated antigen exposure and display highly mutated variable domains. A recent study highlighted a role of IgG2+ memory B cells and allergen-specific IgG2 levels after a 3rd consecutive pre-seasonal sublingual allergen immunotherapy (AIT) with grass pollen tablet. Herein, we aim to explore changes in allergen-specific IgG2 in individuals undergoing house dust mite immunotherapy (HDM-AIT) and explore whether the interrelationship with other humoral responses (i.e., IgG4 and IgE) may discriminate between high and low responders.

中文翻译:

协调的 IgG2 和 IgE 反应作为过敏原免疫治疗效果的标志物

IgG2 反应与反复接触抗原有关,并显示出高度突变的可变结构域。最近的一项研究强调了 IgG2+ 记忆 B 细胞和过敏原特异性 IgG2 水平在连续 3 次使用草花粉片剂进行季节性前舌下过敏原免疫治疗 (AIT) 后的作用。在此,我们旨在探索接受屋尘螨免疫治疗 (HDM-AIT) 的个体中过敏原特异性 IgG2 的变化,并探讨与其他体液反应(即 IgG4 和 IgE)的相互关系是否可以区分高反应者和低反应者。
更新日期:2021-09-22
down
wechat
bug