当前位置: X-MOL 学术Front. Vet. Sci. › 论文详情
Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)
Utility of Computed Tomographic Angiography for Pulmonary Hypertension Assessment in a Cohort of West Highland White Terriers With or Without Canine Idiopathic Pulmonary Fibrosis
Frontiers in Veterinary Science ( IF 3.2 ) Pub Date : 2021-09-23 , DOI: 10.3389/fvets.2021.732133
Eugénie Soliveres 1 , Kathleen Mc Entee 2 , Thierry Couvreur 3 , Aline Fastrès 1 , Elodie Roels 1 , Anne-Christine Merveille 1 , Alexandru-Cosmin Tutunaru 1 , Cécile Clercx 1 , Géraldine Bolen 1
Affiliation  

West Highland white terriers (WHWTs) affected with canine idiopathic pulmonary fibrosis (CIPF) are at risk of developing precapillary pulmonary hypertension (PH). In humans, thoracic computed tomography angiography (CTA) is commonly used to diagnose and monitor patients with lower airway diseases. In such patients, CTA helps to identify comorbidities, such as PH, that could negatively impact prognosis. Diameter of the pulmonary trunk (PT), pulmonary trunk-to-aorta ratio (PT/Ao), and right ventricle-to-left ventricle ratio (RV/LV) are CTA parameters commonly used to assess the presence of PH. Pulmonary vein-to-right pulmonary artery ratio (PV/PA) is a new echocardiographic parameter that can be used in dogs to diagnose PH. The primary aim of this study was to evaluate the use of various CTA parameters to diagnose PH. An additional aim was to evaluate the correlation of RV/LV measurements between different CTA planes. CTA and echocardiography were prospectively performed on a total of 47 WHWTs; 22 affected with CIPF and 25 presumed healthy control dogs. Dogs were considered to have PH if pulmonary vein-to-right pulmonary artery ratio (PV/PA) measured on 2D-mode echocardiography was less than to 0.7. WHWTs affected with CIPF had higher PT/Ao compared with control patients. In WHWTs affected with CIPF, PT size was larger in dogs with PH (15.4 mm) compared with dogs without PH (13 mm, p = 0.003). A cutoff value of 13.8 mm predicted PH in WHWTs affected with CIPF with a sensitivity of 90% and a specificity of 87% (AUC = 0.93). High correlations were observed between the different CTA planes of RV/LV. Results suggest that diameter of the PT measured by CTA can be used to diagnose PH in WHWTs with CIPF.



中文翻译:

计算机断层扫描血管造影在一组患有或不患有犬特发性肺纤维化的西高地白梗中肺动脉高压评估的效用

患有犬特发性肺纤维化 (CIPF) 的西高地白梗 (WHWT) 有发生毛细血管前肺动脉高压 (PH) 的风险。在人类中,胸部计算机断层扫描血管造影 (CTA) 通常用于诊断和监测患有下呼吸​​道疾病的患者。在这些患者中,CTA 有助于识别可能对预后产生负面影响的合并症,例如 PH。肺干直径 (PT)、肺干与主动脉比 (PT/Ao) 和右心室与左心室比 (RV/LV) 是常用于评估 PH 存在的 CTA 参数。肺静脉与右肺动脉之比 (PV/PA) 是一种新的超声心动图参数,可用于犬诊断 PH。本研究的主要目的是评估使用各种 CTA 参数来诊断 PH。另一个目的是评估不同 CTA 平面之间 RV/LV 测量值的相关性。对总共 47 个 WHWT 前瞻性地进行了 CTA 和超声心动图检查;22 只受 CIPF 影响,25 只假定为健康对照犬。如果在 2D 模式超声心动图上测量的肺静脉与右肺动脉之比 (PV/PA) 小于 0.7,则认为狗患有 PH。与对照组患者相比,受 CIPF 影响的 WHWT 具有更高的 PT/Ao。在受 CIPF 影响的 WHWT 中,具有 PH(15.4 毫米)的狗的 PT 大小比没有 PH 的狗(13 毫米,如果在 2D 模式超声心动图上测量的肺静脉与右肺动脉之比 (PV/PA) 小于 0.7,则认为狗患有 PH。与对照组患者相比,受 CIPF 影响的 WHWT 具有更高的 PT/Ao。在受 CIPF 影响的 WHWT 中,具有 PH(15.4 毫米)的狗的 PT 大小比没有 PH 的狗(13 毫米,如果在 2D 模式超声心动图上测量的肺静脉与右肺动脉之比 (PV/PA) 小于 0.7,则认为狗患有 PH。与对照组患者相比,受 CIPF 影响的 WHWT 具有更高的 PT/Ao。在受 CIPF 影响的 WHWT 中,具有 PH(15.4 毫米)的狗的 PT 大小比没有 PH 的狗(13 毫米,= 0.003)。13.8 mm 的临界值预测受 CIPF 影响的 WHWT 的 PH,敏感性为 90%,特异性为 87% (AUC = 0.93)。在 RV/LV 的不同 CTA 平面之间观察到高度相关性。结果表明,CTA 测量的 PT 直径可用于诊断具有 CIPF 的 WHWT 中的 PH。

更新日期:2021-09-23
down
wechat
bug