As mitochondrial dysfunction has increasingly been implicated in neurological diseases, much of the investigation focuses on the response of the mitochondria. It appears that mitochondria can respond to external stimuli speedy fast, in seconds. Understanding how mitochondria sense the signal and communicate with cytosolic pathways are keys to understand mitochondrial regulation in diseases or in response to trauma. It was not until recently that a novel mitochondrial protein, phosphoglycerate mutase family member 5 (PGAM5) has emerged to be a new regulator of mitochondrial homeostasis. Although controversial results reveal beneficial as well as detrimental roles of PGAM5 in cancers, these findings also suggest PGAM5 may have diverse regulation on cellular physiology. Roles of PGAM5 in neuronal tissues remain to be uncovered. This review discusses current knowledge of PGAM5 in neurological diseases and provides future perspectives.

由于线粒体功能障碍越来越多地与神经系统疾病有关，因此大部分调查都集中在线粒体的反应上。似乎线粒体可以在几秒钟内快速响应外部刺激。了解线粒体如何感知信号并与细胞质通路进行交流是了解疾病或应对创伤的线粒体调节的关键。直到最近，一种新的线粒体蛋白磷酸甘油酸变位酶家族成员 5 (PGAM5) 才成为线粒体稳态的新调节剂。尽管有争议的结果揭示了 PGAM5 在癌症中的有益和有害作用，但这些发现也表明 PGAM5 可能对细胞生理有多种调节。PGAM5 在神经元组织中的作用仍有待揭示。