Frizzled receptors (FZDs) are 7-pass transmembrane proteins and members of the G protein-coupled receptor (GPCRs) superfamily. They are classified as WNT receptors and show specific and dynamic expression during different embryonic development stages of invertebrates and vertebrates. They are required in the regulation of developmental processes such as cell specification, cell polarity, and neural patterning in Drosophila, zebrafish, Xenopus, mice, humans, and other animals. The dysfunction of FZDs causes several diseases, including cancer, neural tube defects, and neural degeneration. This review focuses on the structure, signaling, and WNT binding specificity of FZDs as well as their roles in development and diseases, including cancer, embryonic defects, and neurodegenerative disorders. Furthermore, the use of FZDs as potential therapeutic targets for various human diseases is discussed.

卷曲受体 (FZD) 是 7 次跨膜蛋白，是 G 蛋白偶联受体 (GPCR) 超家族的成员。它们被归类为 WNT 受体，并在无脊椎动物和脊椎动物的不同胚胎发育阶段表现出特异性和动态表达。它们是调节果蝇、斑马鱼、非洲爪蟾、小鼠、人类和其他动物的细胞规格、细胞极性和神经模式等发育过程所必需的。FZD 的功能障碍会导致多种疾病，包括癌症、神经管缺陷和神经变性。本综述重点关注 FZD 的结构、信号传导和 WNT 结合特异性，以及它们在发育和疾病（包括癌症、胚胎缺陷和神经退行性疾病）中的作用。此外，