Selective cancer cell targeting, controlled drug release, easy construction and multiple therapeutic modalities are some of the desirable characteristics of drug delivery systems. We designed and built simple capsule-like molecular imprinted polymer (MIP)-based nanoparticles for targeted and chemo-photothermal synergistic cancer therapy. Using dopamine (DA) as functional monomer, cross-linking agent as well as photo-thermal agent, ZIF-8 (zeoliticimidazolate framework-8) as drug carrier, epitope of EGFR (epidermal growth factor receptor) as template molecules, molecular imprinted polymer (MIP) drug carrier was constructed. The ability of MIP layer to bind to EGFR epitope endowed the MD (DOX@MIP) particles to recognize EGFR-overexpressing cancer cells, while the pH-responsiveness and photothermal conversion ability of PDA (polydopamine) achieved chemo-photothermal synergistic effects upon NIR irradiation. Taken together, the MD nanoparticles integrated cancer cell targeting recognition, intelligent drug release, biocompatibility and chemo-photothermal effects, and is therefore a promising tool for targeted cancer therapy with minimal toxicity to normal cells, as well as tumor imaging.

选择性癌细胞靶向、受控药物释放、易于构建和多种治疗方式是药物递送系统的一些理想特征。我们设计并制造了简单的胶囊状分子印迹聚合物 (MIP) 纳米粒子，用于靶向和化学光热协同癌症治疗。以多巴胺（DA）为功能单体、交联剂和光热剂，ZIF-8（zeoliticimidazolate framework-8）为药物载体，EGFR（表皮生长因子受体）表位为模板分子，分子印迹聚合物(MIP)药物载体被构建。MIP层与EGFR表位结合的能力赋予MD（DOX@MIP）颗粒识别EGFR过表达的癌细胞，而PDA（聚多巴胺）的pH响应性和光热转换能力在NIR照射下实现了化学-光热协同效应。总之，MD纳米粒子集成了癌细胞靶向识别、智能药物释放、生物相容性和化学光热效应，因此是一种很有前景的靶向癌症治疗工具，对正常细胞的毒性最小，以及肿瘤成像。