Hydrophilic-lipophilic deviation (HLD) concept describes interaction of surfactant, oil, and water in liquid formulations. Within the framework of HLD, this study investigated the behavior of microemulsion consisting of fragrance/essential oil mixtures and surfactants mixture commonly found in consumer products. Strong non-ideal mixing behavior was seen in oil mixtures of fragrance raw materials. A simple non-ideal relationship was proposed to account for the non-ideality of oil mixture of dissimilar properties. With 95% confidence, the error of the predicted optimum salinity (or phase inversion point) is between 0.70 to 1.68 g/100 mL NaCl in mixtures of complex commercial fragrance and octane. Mixing behavior was also evaluated in a ternary surfactants system consisting of sodium laureth sulfate (SLES), cocamidopropyl betaine (CAPB), and decyl glucoside (APG). Within a reasonable tolerance, the ideal mixing rule can be practically applied for such complex surfactant mixtures. Extension of HLD in mixture systems provides practical benefits in product development.

亲水亲油偏差 (HLD) 概念描述了液体制剂中表面活性剂、油和水的相互作用。在 HLD 的框架内，本研究调查了消费品中常见的由香料/精油混合物和表面活性剂混合物组成的微乳液的行为。在香料原料的油混合物中观察到强烈的非理想混合行为。提出了一个简单的非理想关系来解释不同性质的油混合物的非理想性。以 95% 的置信度，预测的最佳盐度（或相转化点）的误差在 0.70 到 1.68  g/100 之间 mL NaCl 在复杂的商业香料和辛烷的混合物中。还在由月桂醇聚醚硫酸钠 (SLES)、椰油酰胺丙基甜菜碱 (CAPB) 和癸基葡糖苷 (APG) 组成的三元表面活性剂系统中评估了混合行为。在合理的容差范围内，理想的混合规则可以实际应用于这种复杂的表面活性剂混合物。HLD 在混合系统中的扩展为产品开发提供了实际好处。