Construction of biomimetic nanozymes has attracted considerable attention because these artificial enzymes not only exhibited catalytic effects similar to those of natural enzymes, but were also more economical and stable than natural enzymes for a wide range of practical applications. Herein, a peroxidase-like nanozyme was constructed by supramolecular co-assembled strategy, in which horseradish peroxidase active sites (histidine-heme-histidine) were loaded on giant supramolecular tubular scaffolds. The giant nanotube carried a large number of histidine-heme-histidine active sites on the surface thus exhibiting admirable activity with the high apparent second-order rate constant (k_cat[Heme]/K_m) of 572.2 M^-1s^-1 per single heme molecule and also showing high stability. Furthermore, the nanozyme was further applied to detect glucose through test paper by loading with extremely low levels of nanozyme, revealing its potential application in the rapid diagnosis of diabetes.

仿生纳米酶的构建引起了广泛关注，因为这些人工酶不仅表现出与天然酶相似的催化作用，而且比天然酶更经济、更稳定，具有广泛的实际应用前景。在此，通过超分子共组装策略构建了一种类过氧化物酶纳米酶，其中辣根过氧化物酶活性位点（组氨酸-血红素-组氨酸）负载在巨大的超分子管状支架上。巨大的纳米管在表面携带了大量的组氨酸-血红素-组氨酸活性位点，因此表现出令人钦佩的活性，表观二级速率常数（k _cat[Heme] /K _m）为572.2 M ^-1 s ^-1每个血红素分子，也表现出高稳定性。此外，纳米酶通过加载极低水平的纳米酶进一步应用于通过试纸检测葡萄糖，揭示了其在糖尿病快速诊断中的潜在应用。