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Interaction between flucloxacillin and azoles: Is isavuconazole next?
Mycoses ( IF 4.1 ) Pub Date : 2021-09-23 , DOI: 10.1111/myc.13373
Ruth Van Daele 1 , Joost Wauters 2 , Christophe Vandenbriele 3 , Katrien Lagrou 4, 5 , Robin Vos 6 , Yves Debaveye 7 , Isabel Spriet 1
Affiliation  

Isavuconazole is a triazole antifungal drug, approved for the treatment of invasive aspergillosis and mucormycosis. It has been previously reported that an interaction between flucloxacillin and voriconazole may lead to subtherapeutic voriconazole exposure, when used concomitantly. Since isavuconazole is also metabolised via cytochrome P450 enzymes, the same interaction may be expected.

中文翻译:

氟氯西林和唑类的相互作用:接下来是艾沙康唑吗?

艾沙康唑是一种三唑类抗真菌药物,被批准用于治疗侵袭性曲霉病和毛霉菌病。先前曾报道氟氯西林和伏立康唑之间的相互作用,当同时使用时,可能导致亚治疗剂量的伏立康唑暴露。由于艾沙康唑也通过细胞色素 P450 酶代谢,因此可以预期相同的相互作用。
更新日期:2021-11-18
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