Our attention was recently captured by the paper from Freidlin et al.,¹ in which the authors investigate the conditions under which testing non-inferiority with time-to-event data defining the margin as a difference in restricted mean survival time (DRMST) leads to higher power than defining it as a hazard ratio (HR).

中文翻译：

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为什么受限平均生存时间方法对非劣效性试验特别有用

我们的注意力最近被 Freidlin 等人的论文¹吸引，其中作者调查了使用事件发生时间数据测试非劣效性的条件，该数据将边际定义为受​​限平均生存时间 (DRMST) 的差异导致比将其定义为风险比 (HR) 的能力更高。