Determination of Relative Stabilities of Metal-Peptide Bonds in the Gas Phase,Chemistry - A European Journal

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Determination of Relative Stabilities of Metal-Peptide Bonds in the Gas Phase
Chemistry - A European Journal ( IF 3.9 ) Pub Date : 2021-09-23 , DOI: 10.1002/chem.202102385
Monika Cziferszky ₁ , Dianna Truong ₂ , Christian G Hartinger ₂ , Ronald Gust ₁

Affiliation

Breaking bonds: Physiological environments are rich in potential ligands for metal-based drugs and understanding their molecular interactions with biomolecules is pivotal in the design and development of the next generation of metallodrugs. Energy-resolved mass spectrometry allows for measurement of relative bond stabilities in metal-peptide adducts in a quick and simple manner, providing data on the intrinsic properties of the adducts formed.