Synthesis of a Tridecasaccharide Lipooligosaccharide Antigen from the Opportunistic Pathogen Mycobacterium kansasii,Angewandte Chemie International Edition

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Synthesis of a Tridecasaccharide Lipooligosaccharide Antigen from the Opportunistic Pathogen Mycobacterium kansasii
Angewandte Chemie International Edition ( IF 16.1 ) Pub Date : 2021-09-23 , DOI: 10.1002/anie.202111549
Todd Lowary ₁ , Ke Shen ₂ , Bing Bai ₂ , Yu-Hsuan Liu ₂

Affiliation

The tridecasaccharide glycan domain of lipooligosaccharides from the opportunistic pathogen Mycobacterium kansasii was synthesized. The target (see structure) possesses structural motifs that make its synthesis a formidable challenge, including rare monosaccharides, an asymmetrically substituted trehalose residue and a base-sensitive amide side chain. The study provides a strategy for synthesizing other members of this unusual class of molecules.