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trans Single-Stranded DNA Cleavage via CRISPR/Cas14a1 Activated by Target RNA without Destruction
Angewandte Chemie International Edition ( IF 16.6 ) Pub Date : 2021-09-22 , DOI: 10.1002/anie.202110384 Yangdao Wei 1 , Zhiqing Yang 1 , Chengli Zong 1 , Buhua Wang 1 , Xiaolin Ge 1 , Xiao Tan 2 , Xin Liu 3 , Zhenzhen Tao 1 , Peng Wang 4 , Chunxin Ma 1 , Yi Wan 1, 4 , Jinghong Li 2
Angewandte Chemie International Edition ( IF 16.6 ) Pub Date : 2021-09-22 , DOI: 10.1002/anie.202110384 Yangdao Wei 1 , Zhiqing Yang 1 , Chengli Zong 1 , Buhua Wang 1 , Xiaolin Ge 1 , Xiao Tan 2 , Xin Liu 3 , Zhenzhen Tao 1 , Peng Wang 4 , Chunxin Ma 1 , Yi Wan 1, 4 , Jinghong Li 2
Affiliation
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A Cas14a1-based RNA-activated detection platform (Amplification, Transcription, Cas14a1-based RNA-activated trans ssDNA cleavage, ATCas-RNA) has an outstanding specificity for the detection of target RNAs with point mutation resolution, which is better than that of the Cas14a1-based ssDNA-activation.
中文翻译：
通过 CRISPR/Cas14a1 的反式单链 DNA 切割被目标 RNA 激活而不破坏
基于Cas14a1的RNA激活检测平台（Amplification, Transcription, Cas14a1-based RNA-activated trans ssDNA cleavage, ATCas-RNA）对目标RNA的检测具有突出的特异性，点突变分辨率优于基于 Cas14a1 的 ssDNA 激活。
更新日期：2021-10-27
中文翻译：
通过 CRISPR/Cas14a1 的反式单链 DNA 切割被目标 RNA 激活而不破坏
基于Cas14a1的RNA激活检测平台（Amplification, Transcription, Cas14a1-based RNA-activated trans ssDNA cleavage, ATCas-RNA）对目标RNA的检测具有突出的特异性，点突变分辨率优于基于 Cas14a1 的 ssDNA 激活。
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