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An ultra-sensitive immunoassay detects and quantifies soluble Aβ oligomers in human plasma
Alzheimer's & Dementia ( IF 13.0 ) Pub Date : 2021-09-22 , DOI: 10.1002/alz.12457 Lei Liu 1 , Hyunchang Kwak 1 , Trebor L Lawton 2 , Shan-Xue Jin 1 , Angela L Meunier 1 , Yifan Dang 1 , Beth Ostaszewski 1 , Alison C Pietras 1 , Andrew M Stern 1 , Dennis J Selkoe 1
Alzheimer's & Dementia ( IF 13.0 ) Pub Date : 2021-09-22 , DOI: 10.1002/alz.12457 Lei Liu 1 , Hyunchang Kwak 1 , Trebor L Lawton 2 , Shan-Xue Jin 1 , Angela L Meunier 1 , Yifan Dang 1 , Beth Ostaszewski 1 , Alison C Pietras 1 , Andrew M Stern 1 , Dennis J Selkoe 1
Affiliation
Evidence strongly suggests that soluble oligomers of amyloid beta protein (oAβ) help initiate the pathogenic cascade of Alzheimer's disease (AD). To date, there have been no validated assays specific for detecting and quantifying oAβ in human blood.
中文翻译：
一种超灵敏的免疫测定法可检测和量化人血浆中的可溶性 Aβ 寡聚体
有证据表明，β 淀粉样蛋白 (oAβ) 的可溶性低聚物有助于启动阿尔茨海默病 (AD) 的致病级联反应。迄今为止，还没有专门用于检测和量化人体血液中 oAβ 的经过验证的检测方法。
更新日期：2021-09-22
中文翻译：
一种超灵敏的免疫测定法可检测和量化人血浆中的可溶性 Aβ 寡聚体
有证据表明，β 淀粉样蛋白 (oAβ) 的可溶性低聚物有助于启动阿尔茨海默病 (AD) 的致病级联反应。迄今为止，还没有专门用于检测和量化人体血液中 oAβ 的经过验证的检测方法。
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