Cliniatines A–C, new Amaryllidaceae alkaloids from Clivia miniata, inhibiting Acetylcholinesterase,Journal of Natural Medicines

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Cliniatines A–C, new Amaryllidaceae alkaloids from Clivia miniata, inhibiting Acetylcholinesterase
Journal of Natural Medicines ( IF 2.5 ) Pub Date : 2021-09-22 , DOI: 10.1007/s11418-021-01570-6
Yusuke Hirasawa ₁ , Tomoko Tanaka ₁ , Shiro Hirasawa ₁ , Chin Piow Wong ₂ , Nahoko Uchiyama ₃ , Toshio Kaneda ₁ , Yukihiro Goda ₃ , Hiroshi Morita ₁

Affiliation

Cliniatines A–C (1–3), three new Amaryllidaceae alkaloids, consisting of 2,6-dimetylpyridine and lycorine-type and/or galanthamine-type were isolated from Clivia miniata (Lindl.) Bosse. The structures and absolute configurations of 1–3 were elucidated based on spectroscopic data and chemical correlation. Cliniatines A–C showed moderate inhibitory activity against acetylcholinesterase.

Graphic abstract

中文翻译：

Cliniatines A–C，来自 Clivia miniata 的新石蒜科生物碱，抑制乙酰胆碱酯酶

从Clivia miniata (Lindl.) Bosse中分离出Cliniatines A-C ( 1 - 3 )，三种新石蒜科生物碱，由 2,6-二甲基吡啶和石蒜碱型和/或加兰他敏型组成。的结构和绝对构型1 - 3基于光谱数据和化学相关性进行了阐述。Cliniatines A-C 显示出对乙酰胆碱酯酶的中等抑制活性。

图形摘要

更新日期：2021-09-23

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